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In an ATP-dependent process, aminoacyl-tRNA synthetases catalyses the aminoacylation of tRNA.
The carboxyl group of the amino acid is activated by the energy of ATP hydrolysis and forms an ester with one of the cis-diols of the terminal $A 76$ ribose in tRNA.
The triplet anti-codon on the anti-codon end of the produced aa-tRNA is physically connected to the amino-acyl group on the 3′ end of the tRNA, which acts as the genetic code.
In th…

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The integrity of the genome is largely determined by DNA replication fidelity, which is also crucial to the evolution of species and the genesis of human disorders.
Replication fidelity may be influenced by a variety of elements and processes.
The substantially higher level of fidelity that was really attained is largely due to DNA polymerase՚s actions.
DNA polymerase works by assisting with base selection for insertion into newly synthesized DNA, which raises re…

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