Question 1-2 of 12: Structure of Chromatin and Chromosomes (Organization of Genes and Chromosomes) | SWAYAM Cell Biology | Includes PYQs | Get Solutions with Detailed Explanations

The following statements are made with reference to the structure of the nucleosome:

A. The histone tetramer in the core of the nucleosome comprises ${\displaystyle H2A}$ , ${\displaystyle H2B}$, ${\displaystyle H3}$ and ${\displaystyle H4}$.

B. The N-terminal tails of the core histones are believed to stabilize the 30 nm fiber of nucleosome DNA by their interactions with adjacent nucleosomes.

C. The post-translational modifications of the N-terminal tails as well as globular domains of the core histones modulate transcriptional events

D. According to the zigzag model of the 30 nm fiber the linker DNA circles around the central axis of the fiber as the DNA moves from one nucleosome to the next.

Which of the following combinations represents all correct statements? (February Shift 2)

Following statements are made about chromatin remodelling in human cells:

1. Local Chromatin conformation may play more important role than the local DNA sequence of the promoter.

2. Histones in nucleosome can undergo many different covalent modifications, which in turn, alter the chromatin architecture locally.

3. Chromatin remodelling is a developmentally regulated passive process which does not require ATP.

4. Several histone variants exists, which replace the standard histones in specific types of chromatin

Select the option which has the best combination of all correct answers (June)