Homologous and Site-Specific Recombination: Site-Specific Recombination

Site-Specific Recombination

The phrase “site-specific recombination” refers to a collection of procedures in which DNA molecules are altered by severing and reuniting their strands at particular locations.

Two short DNA sequences (sites), which might be found in the same molecule or different molecules, are involved in site-specific recombination.

The sites are identified by a specific recombinase enzyme, which then promotes a DNA rearrangement in which the left end of one s…

… (414 more words) …

Subscribe (by clicking here) to view full notes and track progress.

DNA Damage and Repair Mechanisms

Introduction

DNA is a remarkably robust and stable molecule.

Keeping mutation rates low is essential for the continuity of genetic material from one generation to the next.

DNA repair is not a stand-alone process; rather, it is closely linked to other pathways of nucleic acid metabolism, such as:

• DNA replication
• DNA epigenetic modification
• Transcription
• Cell cycle control
• Induced cell death, as well as processes that are unique to various domains of life, such as telomere mainten…

… (1285 more words, 16 figures) …

Subscribe (by clicking here) to view full notes and track progress.