Formation of Initiation Complex: Interaction between the DNA and Its Binding Proteins

Introduction

The first step in the genome expression was formerly known as ‘transcription’ or “DNA creates RNA, ” but today we understand that this process leading from genome to transcriptome is much complex than just the creation of RNA.

There are now two important stages to this aspect of genome expression.

• The start of transcription, which occurs in the assembly of complex of proteins upstream of the gene, including the RNA polymerase enzyme and its many auxiliary protei…

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Formation of Initiation Complex: The DNA-Protein Interactions During Transcription Initiation Process

The DNA-Protein Interactions During Transcription Initiation Process

RNA Polymerases

• Three distinct RNA polymerases — RNA polymerase I, RNA polymerase II, and RNA polymerase III — are required for the transcription of the eukaryotic nuclear genes.
• Each one is an eight to twelve subunit protein with a molecular mass greater than ${\displaystyle 500kDa}$.
• Although these polymerases are elementally relatively similar to one another — the three…

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